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| Will Ferrell | Megamind | |
| Brad Pitt | Metro Man | |
| Tina Fey | Roxanne Ritchie | |
| Jonah Hill | Tighten | |
| David Cross | Minion | |
| Ben Stiller | Bernard | |
| Justin Theroux | Megamind's Father | |
| Jessica Schulte | Megamind's Mother | |
| Tom McGrath | Lord Scott/Prison Guard | |
| Emily Nordwind | Lady Scott | |
| J.K. Simmons | Warden | |
| Ella Olivia Stiller | Schoolchild | |
| Quinn Dempsey Stiller | Schoolchild | |
| Brian Hopkins | Prisoner | |
| Christopher Knights | Prison Guard | |
| Will Ferrell | ||
| Brad Pitt | ||
| Tina Fey | ||
| Jonah Hill | ||
| David Cross | ||
| Ben Stiller | ||
| Justin Theroux | ||
| Jessica Schulte | ||
| Tom McGrath | ||
| Emily Nordwind | ||
| J.K. Simmons | ||
| Ella Olivia Stiller | ||
| Quinn Dempsey Stiller | ||
| Brian Hopkins | ||
| Christopher Knights |
| Director |
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| Producer |
Guillermo del Toro
Ben Stiller |
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| Writer |
Brent Simons
Alan Schoolcraft |
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Bumbling supervillain Megamind finally defeats his nemesis, the superhero Metro Man. But without a hero, he loses all purpose and must find new meaning to his life. |
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